Sulfates are the most important circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The primary oxidative metabolite is two-hydroxy ethinyl estradiol, shaped via the CYP3A4 isoform of cytochrome P450. Portion of the main-pass metabolism of ethinyl estradiol is thought to manifest in gastrointestinal mucosa. Ethinyl es